Vine Tea (Ampelopsis grossedentata) and Its Bioactive Components

Vine Tea (Ampelopsis grossedentata) and Its Bioactive Components

Vine tea (Ampelopsis grossedentata) is an ancient herbal medicine and beverage consumed for its anti-inflammatory, hepatoprotective, and vascular-enhancing properties.vine tea Until recently, it has been unclear how vine tea exhibits its biological activities.vine tea The flavonoid dihydromyricetin is believed to be responsible for these effects, but the diversity of metabolites in different cultivars remains largely unexplained. We employ UPLC-Q-TOF-MS to elucidate the chemical profile of vine tea and identify the major flavonoids dihydromyricetin, isoquercitrin, and myricetin. The UPLC-Q-TOF-MS results were then verified by Western blotting and immunofluorescence staining. Furthermore, we used a liver model to test the anti-ALD effects of AGE and found that it alleviated chronic ethanol consumption-induced hepatic lipid accumulation, oxidative stress, and inflammation. Moreover, the hepatoprotective effects of AGE were further validated by transcriptomics and weighted gene co-expression network analysis. Interestingly, a YTHDF2/PGC-1/SIRT3 signaling axis is responsible for the anti-ALD effects of AGE.

Our findings suggest that dietary supplementation of VTE may provide a promising strategy for the prevention and treatment of obesity, cardiovascular disease, and hypertension.vine tea Additionally, we show that the cellular mechanisms by which AGE protects against hepatic injury are dependent on its redox-related signaling pathways and gut microbiota. We propose that these redox-related pathways are essential for maintaining normal adipose tissue function and normal energy metabolism, as well as preventing hepatic lipid accumulation and chronic alcoholic liver disease.

The main functional component of the vine tea (DHM) is a polyphenol called dihydromyricetin, which has been shown to exhibit several health benefits.vine tea For example, DHM is known to prevent diabetes and obesity by inhibiting the progression of pre-adipocytes into mature adipocytes and by suppressing lipid accumulation in mature adipocytes, while also increasing lipolysis and energy metabolism. In addition, DHM is also known to ameliorate alcohol-induced hepatitis by reducing oxidative damage and inflammation and by modulating the microbial community in the gut of alcoholics. In this article, we present the underlying molecular mechanism of these effects of DHM on metabolic syndromes (MS) by targeting the redox associated signaling pathways such as Nrf2/ARE, NF-kB/JNK, PI3K/IRS2/AKT insulin resistance pathway, and AMPK-PGC1a-SIRT3 energy metabolism related pathway. Furthermore, we also document the effects of DHM on the regulation of intestinal microbial microecology by upregulating the ratio of Firmicutes to Bacteroidetes and downregulating the relative abundance of Akkermansia muciniphila in obese mice fed with high-fat diet. This article will provide important theoretical basis and molecular evidence for future development of dietary functional products or drugs against MS via the interplay between vine tea/DHM, redox associated signaling pathways, and the gut microbiota.